Caspase-4 (homolog of mouse caspase-11) is a non-canonical inflammasome detected cytoplasmic LPS to active GSDMD and involved in pyroptotic cell death implicated in infectious diseases,5 but it is unclear whether and how caspase-4 senses host-derived endogenous factors to trigger pyroptosis in noninfective diseases. This evidence concerns the gene CASP4 and infectious disease.