SOD2 and Alzheimer disease: Strikingly, semi-quantitative densitometry of signal intensities from immunoblots (Fig. 6a, b) showed that the steady-state expression levels of VDAC 1, MnSOD, TOMM 20, and Cyt c were downregulated in Tg2576 AD mice in comparison with their littermate wild-type controls (***p < 0.0005; **p < 0.01) but significantly rescued after i.v. administration of 12A12mAb (***p < 0.0005; **p < 0.01).