MAPT and Alzheimer disease: By taking advantage of this well-established tau-directed immunization protocol, we investigated symptomatic (6-month-old) Tg2576 transgenic mice to assess whether: (i) tau cleavage contributes to altering several biochemical, morphological and metabolic parameters of their retina and vitreous body; (ii) 12A12mAb i.v. delivery is able to exert a protective action on the signs of ocular injury associated with the AD phenotype, as shown to occur for the brain parenchyma.