APP and Alzheimer disease: By probing retinal extracts from animals’ cohorts with the anti-Aβ/APP protein 6E10 (4-9aa) antibody (Fig. 2c, d), an increase in the expression level of APP full length holoprotein along with a prominent heterogeneous ladder of Aβ sequence-containing processing intermediates ranging between 14 and 70 kDa was clearly discernible in 6-month-old Tg2576 AD mice when compared with littermate wild-type controls (***p < 0.0005).