MAPT and Alzheimer disease: Besides, these findings confirm previous investigations reporting that the genetic reduction of tau expression by intravitreal injection of targeted siRNA, ameliorates the axonal transport [63], the synaptic and mitochondrial defects [108] in 3xTg AD mice and in a High-Fat Diet (HFD)-induced animal model of diabetic retinopathy, leading to improvement of their visual abnormalities [108].