hsa_circ_0065336 and PTPN11 expression was up-regulated in a time-dependent manner, reaching a peak at 12 h (P = 0.033 and 0.029, respectively) (Fig. 6a, b), whereas miR-505-3p expression was down-regulated starting at 3 h after infection (Fig. 6c) and then was maintained at a decreased level at 9 h after infection (P = 0.021), which was highly similar to the RNA-seq results. The gene discussed is PTPN11; the disease is infection.