AKT1 and central nervous system cancer: This group discovered that the oncogenic form of the epidermal growth factor receptor (EGFRvIII), which causes oncogenesis by activating the signaling pathways MAPK and Akt and regulating gene expression of VEGF, Bcl-x(L) and p27, was actively transferred via microvesicles termed “oncosomes” between glioma cells resulting in their transformation [16].