Results showed that the expression of NF-kκB/p65, p-NF-kκB/p65, JNK, p-JNK, c-Jun and p-c-Jun in both the two NASH model were increased, and the expression levels of the above proteins were significantly decreased after interfering with LncRNA-gm9795 (Fig. 6a, b). Here, MAPK8 is linked to metabolic dysfunction-associated steatohepatitis.