Our study found that LncRNA-gm9795 in NASH in vitro model significantly activates the expression of IRE1\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha {}$$\end{document}α and BIP, which are key molecules of endoplasmic reticulum stress. Here, HSPA5 is linked to metabolic dysfunction-associated steatohepatitis.