For example, Aβ peptide-derived diffusion ligands (ADDLs) [112], APP [113], BACE1 [114], α-1-antitrypsin (AAT) [115], Alzheimer-associated neuronal thread protein (AD7c-NTP) [116], and NFL [117] are some significant AD biomarkers that have attracted tremendous research interest. The gene discussed is BACE1; the disease is Alzheimer disease.