APOE and Alzheimer disease: Incessant research on AD has uncovered additional factors such as apolipoprotein-E (ApoE) [12] on chromosome 19, amyloid-β-derived diffusible ligands (ADDLs) [13], α-1-antitrypsin (AAT) [14], A disintegrin and metalloprotease 10 (ADAM10) [15], beta-secretase or beta-site APP cleaving enzyme I (BACE1) [16], and Alzheimer’s disease-associated neuronal thread protein (AD7c-NTP) [17].