Our results demonstrated a significant relationship between GLUT-1/MACC1 expression and T status (P = 0.006 and 0.002), differentiated degree (P = 0.009 and 0.014), CRC patients with high T-status and poorly differentiated tended to have higher GLUT-1/MACC1 expression levels. Here, MACC1 is linked to colorectal carcinoma.