MMP2 and lung adenocarcinoma: However, sevoflurane may also suppress malignant progression in some cancer cell types through a decreased release of matrix metalloproteinase-2 (MMP-2) and MMP-9, partly due to inactivation of the p38 mitogen-activated protein kinase signaling pathway in lung adenocarcinoma cells, resulting in anti-invasion and anti-migration effects [156].