Moreover, ECHDC1 was identified much less frequently as an outlier by a simpler approach to identify CCS in each individual study based on the METH data modality alone (Appendix Fig S3E), or using an integrative multi‐omics factor analysis approach MOFA+ (see Methods and Protocols, Appendix Fig S3D), highlighting the usefulness of CLIP in identifying novel cancer‐associated genes through robust integration of multi‐modal multi‐site datasets. Here, ECHDC1 is linked to cancer.