On the contrary, caloric restriction is able to ameliorate the blunted PYY‐release seen in obesity leading to increased PYY‐release in response to a high‐fat meal,47 while increased postprandial secretion of PYY after Roux‐en‐Y gastric bypass contributes to appetite reduction and weight loss after surgery.48 This evidence concerns the gene PYY and obesity due to melanocortin 4 receptor deficiency.