On the contrary, caloric restriction is able to ameliorate the blunted PYY‐release seen in obesity leading to increased PYY‐release in response to a high‐fat meal,47 while increased postprandial secretion of PYY after Roux‐en‐Y gastric bypass contributes to appetite reduction and weight loss after surgery.48 The gene discussed is PYY; the disease is obesity disorder.