Almeida et al. (2019) showedthat RSV has antiproliferative effects in bladder cancer cells independent of theTP53 gene status (RT4 - TP53 wild type,transitional cell carcinoma, 5637 and T24 - TP53 mutant).TP53 gene is considered the guardian of the genome, because itresponds to stress signals inducing cell cycle arrest, apoptosis or DNA repair(Kastenhuber and Lowe, 2017).TP53 mutations are common in muscle-invasive bladder cancer andare correlated with poor prognosis (Solomon andHansel, 2016). This evidence concerns the gene TP53 and transitional cell carcinoma.