RASSF1 and urinary bladder cancer: In T24cells, RSV treatment also caused modulation of pathways connected toRASSF1A and HOXB3 genes.RASSF1A is a tumor suppressor gene, whose promoter regionhypermethylation causes its inhibition in many cancers, including bladder cancer(Baylin and Herman, 2000).RASSF1A silencing occurs through the HOXB3oncogene that induces DNMT3B expression, a gene that encodes a DNAmethylation enzyme.