SHH and neoplasm: Upon assessing the expression of PD-L1 on TAMs in Shh-KO tumor samples, we found that deletion of Shh in tumor cells also resulted in reductions of PD-L1 expression on TAMs, both in the Hepa1-6 (Figure 6C) and in the LLC1 (P < 0.005; Figure 6E) tumor models.