Here we found that intratumor CD8+ T cells isolated from SmoΔM tumor-bearing mice produced significantly higher IFN-γ and GzmB (P < 0.005) when compared with Smofl/fl (Figure 5A), suggesting that Hh-induced M2-polarized TAMs could suppress intratumor CD8+ T cell function. This evidence concerns the gene GZMB and neoplasm.