These two methods might detect different status/types of astrogliosis, as 1) GFAP is expressed non-uniformly on subtypes of astrocytes [67]; 2) change in glia phenotype profiles but not number of GFAP + astrocytes in AD brain; 3) MAO-B expressed in astrocytes as well as in dopaminergic neurons mainly in subcortical regions. Here, MAOB is linked to Alzheimer disease.