CD22 and Autoimmunity: BCR-regulating surface proteins like CD22 or sialic acid-binding immunoglobulin-type lectins have been related to development of autoimmunity and point out BCR-mediated calcium flux as an important component, not only during B cell development but also in their differentiation to effector cells (Hoffmann et al., 2007; Jellusova et al., 2010; Müller and Nitschke, 2014; Nitschke and Tsubata, 2004; O'Keefe et al., 1999).