Consistent with the association between the endosomal trafficking system and pathology, dominant missense mutations in WASHC5 (protein: Strumpellin) are associated with hereditary spastic paraplegia (SPG8) (de Bot et al., 2013; Valdmanis et al., 2007), and autosomal recessive point mutations in WASHC4 (protein: SWIP) and WASHC5 are associated with syndromic and non-syndromic intellectual disabilities (Assoum et al., 2020; Elliott et al., 2013; Ropers et al., 2011). This evidence concerns the gene WASHC5 and hereditary spastic paraplegia.