In particular, mutations associated with Parkinson’s disease have been found in a close endosomal interactor of the WASH complex – the retromer protein VPS35 (VPS35D620N and VPS35R524W) – and have been linked to pathological α-synuclein aggregation in vitro (Chen et al., 2019; Follett et al., 2014; Tang et al., 2015). Here, SNCA is linked to Parkinson disease.