Notable exceptions relevant to IRD include variants in the non‐coding region upstream to PRDM13 associated with North Carolina Macular Dystrophy (Small et al., 2016) (OMIM 13650) and CEP290:c.2991+1655A>G, a prevalent cause of LCA in European patients (Sheck et al., 2018). This evidence concerns the gene CEP290 and Leber congenital amaurosis.