MAEL is a novel cancer/testis‐associated gene, which is not only aberrantly expressed in various cancer tissues but also characterized as a tumor‐promoting factor through activating Akt and regulating the phosphorylation of nuclear factor kappa B.33, 34The functions of CMSS1 were seldom studied; however, the upregulation of CMSS1 was an observer in immortalized cells, cancer cells, and non‐small‐cell lung cancer tissues.35 Here, MAEL is linked to cancer.