Therefore, according to the in vivo and in vitro results obtained in this study, a molecular mechanism (Figure 8) was established to explain the role of LINC00470 in reducing the stability of PTEN via RNA methyltransferase METTL3, which in turn led to the inhibition of cell autophagy as well as the promotion of chemoresistance in CML. This evidence concerns the gene METTL3 and chronic myelogenous leukemia, BCR-ABL1 positive.