BCR and leukemia: As a type of bone marrow malignancy featured by the generation of breakpoint cluster region (BCR) as well as the formation of Abelson murine leukemia (ABL) gene encoding BCRABLp210, chronic myeloid leukaemia (CML) can be specifically divided into 3 phases, that is chronic phase (CP), accelerated period (AP), as well as blast phase (BP), while advanced CML is characterized by the AP and BP phases of CML.1, 2, 3