The findings of this study demonstrated that LINC00470 is a regulator of METTL3, and the deregulation of the LINC00470/METTL3 signalling pathway promoted chemoresistance and suppressed autophagy of CML cells by modulating the stability of PTEN and activing AKT. This evidence concerns the gene METTL3 and chronic myelogenous leukemia, BCR-ABL1 positive.