The findings of this study demonstrated that LINC00470 is a regulator of METTL3, and the deregulation of the LINC00470/METTL3 signalling pathway promoted chemoresistance and suppressed autophagy of CML cells by modulating the stability of PTEN and activing AKT. Here, AKT1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.