LRRK2 and Parkinson disease: For example, the LRRK2 p.G2019S variant confers an approximately 25% lifetime risk of Parkinson's disease (minor allele frequency = 0.15%, odds ratio = 11.3 in Europeans), whereas a common variant (rs76904798, minor allele frequency = 14.4% in Europeans) that is linked to a LRRK2 expression quantitative trait locus (eQTL, see Glossary of terms) is associated with an odds ratio of 1.15 [120].