Currently, evidence on the interaction between APOE genotype and dietary factors with dementia has mostly focused on dietary patterns and dietary fat intake; those studies found older individuals (aged ≥60 y) who had a diet high in fatty fish or higher polyunsaturated fat intake were associated with a decreased risk of all-cause dementia, especially among APOE ε4 noncarriers (31, 32). Here, APOE is linked to dementia.