For instance, in a stab injury model, SAG results in an increase in the number of newly proliferating GFAP+ cells.27 Similarly, following an ischemic stroke, progenitors from the SVZ migrating into the ischemic tissue are increased following SAG treatment.28 Therefore, in models of injury that lead to cells acquiring stem-like properties at the injury site, activation of Shh signaling by SAG acts to increase the stem/progenitor response. Here, SHH is linked to ischemic stroke.