Tangeretin derivative 5-acetyloxy-6, 7, 8, 4′-tetramethoxyflavone (5-AcTMF) was reported to induce autophagy in CL1-5 non-small cell lung cancer (NSCLC) by inducing the synthesis of autophagosome as well as increasing the expression of microtubule-associated proteins 1A/1B light chain 3B (LC3-II) and LC3 [62]. The gene discussed is MAP1LC3A; the disease is non-small cell lung carcinoma.