The anti-inflammatory effect of tangeretin has been reported in different pathological conditions such as allergic rhinitis via stimulating regulatory T cell [65], asthma by regulating phosphoinositide 3-kinase (PI3K) pathway [21], and Respiratory Syncytial Virus-induced inflammation by curbing NF-κB and interleukin-1 beta (IL-1B) [23]. The gene discussed is IL1B; the disease is allergic rhinitis.