It is important to recognize that all three NOS isoforms play a role in sepsis, but tissue location and eNOS uncoupling deserve special considerations (Duma et al., 2011; Farah et al., 2018; Gross et al., 2015; Ichinose et al., 2007; Mao et al., 2013; van de Sandt et al., 2013; Wang et al., 2004; Yamashita et al., 2000). Here, NOS1 is linked to Sepsis.