ADIPOQ and obesity due to melanocortin 4 receptor deficiency: In humans, adiponectin is synthesized by the AdipoQ gene, on chromosome 3 (3q27) and has polymorphisms such as the single nucleotide polymorphism (SNP) + 45T > G (rs 2241766), located in exon 2, whose variations may be related to serum changes in adiponectin [12], obesity [13,14] and insulin resistance [15]; however, its role in SCT patients with MS has not yet been studied.