A study using a liver cancer malignant ascites (MA) model showed that HIF1α expression and PI3K/Akt/mTOR/p70 ribosomal protein S6 kinase (p70S6K) pathway activation could be inhibited by microRNA (miR-145), which led to suppression of Th9 differentiation and IL-9 production in MA [209]. This evidence concerns the gene RPS6KB1 and microtia.