On the other hand, the downregulated genes, such Bnip3 Gm45507 and Dgkg, were involved in phosphatidylinositol signaling system, legionellosis, glycerophospholipid metabolism, glycerolipid metabolism, FoxD signaling pathway, and choline metabolism (Figure 5B and Supplementary Datasheet 4). This evidence concerns the gene BNIP3 and legionellosis.