Additionally, results of KEGG pathway analysis indicated that apoptosis-related genes were mainly enriched in Cytokine-cytokine receptor interaction, Allograft rejection, Epstein-Barr virus infection, Primary immunodeficiency, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, NF-kappa B signaling pathway and Th17 cell differentiation (Figure 1D, Supplementary Table S3). Here, AKT1 is linked to Epstein-Barr virus infection.