Interestingly, we found that both subgroups shared a spectrum of alterations in 13 genes (CYP1B1, CASP8, BAP1, PIK3CA, TERT, CDKAL1, CDKN2A, TYR, POLE, OCA2, TERF2IP, MC1R, MGMT), which suggests that they may have role in the development of melanoma. The gene discussed is OCA2; the disease is melanoma.