POLE and melanoma: Interestingly, we found that both subgroups shared a spectrum of alterations in 13 genes (CYP1B1, CASP8, BAP1, PIK3CA, TERT, CDKAL1, CDKN2A, TYR, POLE, OCA2, TERF2IP, MC1R, MGMT), which suggests that they may have role in the development of melanoma.