We constructed a 15-ferroptosis mRNA signature for predicting the prognosis of ovarian cancer, composed of CDKN1B, CXCR4, FAS, FOS, FOXO1, GABARAPL1, HDAC1, IFNG, IL24, MTMR14, NFKB1, PEX3, PPP1R15A, RB1, and SIRT2. The gene discussed is CDKN1B; the disease is ovarian cancer.