We constructed a 15-ferroptosis mRNA signature for predicting the prognosis of ovarian cancer, composed of CDKN1B, CXCR4, FAS, FOS, FOXO1, GABARAPL1, HDAC1, IFNG, IL24, MTMR14, NFKB1, PEX3, PPP1R15A, RB1, and SIRT2. This evidence concerns the gene SIRT2 and ovarian cancer.