As showed in Figure 4, the results showed all of 6 m6A regulators (HNRNPC, YTHDC2, WTAP, VIRMA, IGF2BP3, and HNRNPA2B1) were up-regulated in both Esophageal squamous cell carcinoma and esophageal adenocarcinoma compared to normal samples. The gene discussed is VIRMA; the disease is esophageal squamous cell carcinoma.