In conclusion, ZINC21710815 significantly decreased the proliferation of K562, BaF3/WT, and BaF3/T315I leukemia cells due to it (1) producing cell cycle arrest; (2) inducing apoptosis; and (3) inhibiting the phosphorylation of BCR-ABL kinase and the downstream targets, STAT5 and Crkl, in BaF3/WT leukemia cells. Here, CRKL is linked to leukemia.