The p210 protein is a constitutively active, non-receptor tyrosine kinase that phosphorylates its Tyr177 residue, which subsequently activates a number of downstream signaling pathways that causes HSC cells undergo significant abnormal proliferation and differentiation compared to normal cells, producing the pathogenic changes reported in CML patients (Deininger et al., 2000; Gora-Tybor and Robak, 2008; Cao et al., 2015; Wang et al., 2016). This evidence concerns the gene EVPL and chronic myelogenous leukemia, BCR-ABL1 positive.