The role of CRABP2 and NUSAP1 in pancreatic cancer is currently unclear, but CRABP2 and NUSAP1 favors proliferation and invasion of several types of tumor, such as prostate, lung, gastric and colorectal cancer (Gordon et al., 2017; Han G. et al., 2018; Wu et al., 2019; Ge et al., 2020; Xu et al., 2020). Here, CRABP2 is linked to familial pancreatic carcinoma.