TP53 and familial pancreatic carcinoma: These pathways included DNA damage response pathways like nucleotide excision repair, mismatch repair, homologous recombination and base excision repair; cell cycle related pathways like cell cycle, p53 signaling pathway, DNA replication and oocyte meiosis; RNA metabolism related pathways like spliceosome, RNA degradation, aminoacyl tRNA biosynthesis; and cancers like pancreatic cancer, small cell lung cancer (Figures 7A–J and Supplementary Table 4).