Based on the transcriptomics profiling of anlotinib in this work and available pancreatic cancer related data deposited in TCGA, GEO, and ICGC databases, we further constructed a prognostic model which consists of five crucial genes, namely TOP2A, CRABP2, CDK1, NUSAP1, and PERP. This evidence concerns the gene PERP and familial pancreatic carcinoma.