Myocardial biopsy analysis on 24 patients who died of CKD indicated that 67% of them had LVH, which was characterized by significantly expressed FGFR4, NFAT, and klotho deficiency compared with the control group (Leifheit-Nestler et al., 2016). Here, KL is linked to hyperinsulinemic hypoglycemia, familial, 4.