Despite the fact that multiple lncRNAs, such as HOTAIR (Lv et al., 2013), CCAT2 (Zhang et al., 2015), and MALAT1, display potential prognostic value in ESCC (Cao et al., 2015; Deng et al., 2016), the role of immune-related lncRNA signatures in prognosis has not been clarified in literature. This evidence concerns the gene CCAT2 and esophageal squamous cell carcinoma.