In addition, the reprogramming of TAMs toward M1-like macrophages is also regulated by TCM active components such as β-elemene (βe), which reduces the expression of Vimentin, N-cadherin, and Arg-1, and upregulates the expression of E-cadherin and iNOS to regulate the poles of macrophages from M2 to M1, inhibiting the proliferation, migration, and invasion of lung cancer cells (Yu et al., 2017) (Figure 1 and Table 3). This evidence concerns the gene ARG1 and lung cancer.