What is more, the reprogramming of TAMs toward M1-like macrophages is regulated by TCM Herbs, such as Crocus sativus L, which can elevate the expression of IL-1β and TNF-α to induce the development of a polarized phenotype of M1-like macrophages after tumor antigen stimulation, restoring their antigen presentation ability in human melanoma. The gene discussed is TNF; the disease is neoplasm.