STAT3 and neoplasm: Qing-Re-Huo-Xue (QRHX) formulae increases the expression of iNOS and decreases the expression of IL-6, TNF-α, and Arg-1 through the JAK2/STAT3 pathway, further reducing the numbers of TAMs and inhibiting tumor growth in lung cancer mouse model (Xu et al., 2017) (Figure 2 and Table 4).