Cao M. et al. (2019) found that PGDN significantly reduced the level of CD206 in M2-like macrophages and upgraded the expression of CD80, CD86, MHC-II, and TLR2/4 to induce the increased numbers of M1 macrophages, reducing tumor growth in vaccinated mice and human melanoma cells (Figure 1 and Table 4). This evidence concerns the gene MRC1 and neoplasm.