Compared with the 3T3 feeder cells, mouse collagen type IV, and basement membrane matrix Matrigel extracted from mouse sarcoma in the traditional culture system, human fibronectin can prevent the transmission of unknown zoonoses, which is critical for the clinical application of hHFSCs (Limat et al., 1989; Li et al., 2015; Call et al., 2018). This evidence concerns the gene FN1 and sarcoma.