IFT20 controls lysosome maturation by regulating the retrograde transport of cation-independent mannose-6-phosphate receptors (CI-M6PR) (Finetti et al., 2020); additionally, it affects osteosarcoma cell migration by regulating the dynamics of Golgi-associated microtubules (Nishita et al., 2017). The gene discussed is IFT20; the disease is osteosarcoma.