The perspective that dysregulated axoneme glutamylation might be a central etiology in JBTS was further strengthened by the finding that the Joubert syndrome protein ARL13B associates with FIP5, a known effector of another ciliary GTPase RAB11, to promote the ciliary import of tubulin glutamylases TTLL5 and TTLL6 in human epithelial cells (He et al., 2018). This evidence concerns the gene TTLL5 and Joubert syndrome.