Furthermore, in pharmacological studies using hyperforin, one of the main natural compounds of the medicinal plant Saint John’s wort that acts as an antidepressant drug (Zanoli, 2004) and TRPC6 activator (Tu et al., 2010), or tetrahydrohyperforin, a stable semisynthetic compound derived from hyperforin (Rozio et al., 2005), TRPC6 was shown to play a potential role in AD through the reduction of Aβ accumulation due to increased cerebrovascular P-glycoprotein (Brenn et al., 2014) and increased adult hippocampal neurogenesis and long-term spatial memory (Abbott et al., 2013), respectively. The gene discussed is TRPC6; the disease is Alzheimer disease.