Using a pilocarpine (muscarinic agonist)-induced status epilepticus (PISE) model, studies have shown that the genetic elimination of TRPC3 reduces the susceptibility of seizures to pilocarpine, while enhancing the expression of TRPC3 induces hyperexcitability and increases susceptibility to epileptiform activity in the cortex (Zhou and Roper, 2014; Phelan et al., 2017). The gene discussed is TRPC3; the disease is status epilepticus.