The activation of TRPC1 channels has been reported to induce neuroprotection against apoptosis in SH-SY5Y neuroblastoma cells (Bollimuntha et al., 2006), as well as to regulate SOCE channels and reduce DA neuronal cell death in the SN of TRPC1 KO mice (Selvaraj et al., 2009, 2012). This evidence concerns the gene TRPC1 and neuroblastoma.