However, knockdown by siTRPC5 and inhibition of TRPC5 with ML204, a selective TRPC4 blocker produced by the Molecular Libraries Probe, produces a protective effect against oxidative stress in Q111 HD striatal cells and improves motor behavior in HD Tg mice (Miller et al., 2011; Hong et al., 2015, 2020a). This evidence concerns the gene TRPC5 and Huntington disease.