In contrast, iNOS mRNA was not up-regulated upon infection or LPS-stimulation in TLR-5-fold-/- (Figure 3B), MyD88-/- (Figure 3C) and MyD88-/- TRIF-/- (Figure 3D) Hoxb8 neutrophils compared to the respective uninfected or unstimulated control cells. Here, NOS2 is linked to infection.