It was once detected in a young Chinese patient with FH in 2016 (Jiang et al., 2016).This mutation is in the exon 12 which is within the EGF precursor homology domain (i.e. exon 7–14), and is involved in the dissociation of the receptor and the lipoprotein in the endocytosis machinery (Zhang et al., 2007). Here, EGF is linked to familial hyperaldosteronism.