NOS2 and cancer: Conversely, a higher infiltration of M1 TAMs—defined by high expression of IL-1β, inducible nitric oxide synthase (iNOS), CD80, CD86, and MHC class II molecules—correlates with good outcome in selected cancer types, including non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), ovarian and gastric cancers (3).