IL10 and neoplasm: M2 TAMs are directly suppressive to T cell responses, e.g., via upregulation of PD-L1 and release of IL-10, transforming growth factor-β (TGF-β) and reactive oxygen species (ROS)—as well as indirectly, via modulation of the tumor microenvironment, including recruitment of Tregs and inhibition of dendritic cells (DCs) (4).