CD38 is a type II transmembrane glycoprotein and multifunctional ectoenzyme involved in calcium mobilization, cell adhesion and signaling pathways (23).In this study, more than 55% of the tumor-infiltrating CD8+ T cells in NSCLC patients were CD38+, which was significantly higher than the proportion in normal lung tissues. This evidence concerns the gene CD8A and non-small cell lung carcinoma.