Purinergic cell surfaces ectoenzymes (P2Xs, P2Ys, CD73, CD39, and CD38), mediate the biological activities of ATP and Adenosine, and adenosine receptors (A1R, A2AR, A2BR, A3R), are overexpressed by breast cancer cells and tumor-infiltrating immune cells (19). The gene discussed is ENTPD1; the disease is breast carcinoma.