Purinergic cell surfaces ectoenzymes (P2Xs, P2Ys, CD73, CD39, and CD38), mediate the biological activities of ATP and Adenosine, and adenosine receptors (A1R, A2AR, A2BR, A3R), are overexpressed by breast cancer cells and tumor-infiltrating immune cells (19). Here, ADORA2A is linked to breast cancer.