In our study, GI-DLBCL exhibited high-frequency mutations in B2M, CCND3, HIST1H1C, BIRC6, TET2, KMT2C, LRP1B, CSMD3, FAT4, RHOA, MUC4, and FBN2, revealing consistent mutation frequencies and variants in common with DLBCL in cBioPortal and COSMIC. This evidence concerns the gene RHOA and diffuse large B-cell lymphoma.