CREBBP and diffuse large B-cell lymphoma: GI-DLBCL exhibited a higher mutation frequency in TP53 than nodal DLBCL (P = 0.010) and a lower mutation frequency in KMT2D (P = 0.020), BCL2 (P = 0.008), CREBBP (P = 0.008), and EZH2 (P = 0.008; Figure 4B).