In addition to mutations in the KMT2D, MYD88, CREBBP, BCL2 and EZH2 genes, PIM1 and CARD11 gene mutations were also observed at a lower frequency in GI-DLBCL than in common or nodal DLBCL (32, 33); however, the difference was not statistically significant in this study (Figure 4 and Supplementary Table 3). This evidence concerns the gene CARD11 and diffuse large B-cell lymphoma.