Intriguingly, although CD79B mutations were detected in two patients (8%) with GI-DLBCL, the frequency was significantly reduced compared with that in the testes (18.9~71.4%) (9, 11, 37) and central nervous system (31.6~61.1%) DLBCLs (36, 38, 39). Here, CD79B is linked to diffuse large B-cell lymphoma.