GCB-DLBCL tumors harbored more mutations in BCL2, EZH2, CREBBP, KMT2D, SGK1, BCR, NBEA, P2RY8, HUWE1, and TNFRSF14, while ABC-DLBCL tumors harbored more mutations in MYD88, PIM1, CD79B, and TBL1XR1. However, the mutation frequencies and variants observed in 6 patients with GCB-DLBCL and 19 patients with non-GCB-DLBCL in our study were not different. Here, P2RY8 is linked to diffuse large B-cell lymphoma.