EZH2 and diffuse large B-cell lymphoma: In our previous study, the EZH2 Y641 mutation was successfully detected in one of 94 patients with GI-DLBCL (including 33 patients with GCB-DLBCL and 61 patients with non-GCB-DLBCL) by Sanger sequencing, and the mutation frequency was significantly reduced compared with that in non-gastrointestinal DLBCL (16).