Moreover, compared with nodal DLBCL in MSK-IMPACT, GI-DLBCL also exhibited a significantly lower mutation frequency of KMT2D (P = 0.003), PIM1 (P = 0.035), BCL2 (P = 0.016), CREBBP (P = 0.000) and EZH2 (P = 0.036) in our study (Supplementary Table 3). Here, BCL2 is linked to diffuse large B-cell lymphoma.