LoF alleles were most common in ATM (14 variants), BRCA2 (6), PALB2 (4), and BRCA1 (3), as well as CFTR (6), which is linked to the development of chronic pancreatitis, a disease that associates with pancreatic cancer development (2, 3, 18–21). The gene discussed is BRCA1; the disease is chronic pancreatitis.