In this study on 148 B-ALL pediatric patients from India, which were treated with ICiCLe protocol (a modified BFM protocol), we aimed to evaluate the association between response to prednisolone of ALL patients, as assessed by day 8 PB blast counts, with mRNA expression levels of CASP1, NLRP3, and EMP1 genes. The gene discussed is NLRP3; the disease is acute lymphoblastic leukemia.