CASP1 and NLPR3 levels were lower in ALL patients compared to controls (CASP1: all cases versus controls p=0.0002, Supplementary Figure 1B; PPRs versus controls p=0.0017 and PGRs versus controls p=0.0003, Figure 1B and NLRP3 all cases versus controls p<0.0001, Supplementary Figure 1C; PPRs versus controls p<0.0001 and PGRs versus controls p<0.0001, Figure 1C). Here, NLRP3 is linked to acute lymphoblastic leukemia.