proposed three subgroups which were consistent with (albeit less granular than) the aforementioned analysis: immune active (enriched by proinflammatory M1 macrophage signature, with increased cytolytic activity and tumor infiltrating lymphocytes, and high incidence of HPV infection); immune exhausted (enriched by activated stroma and anti-inflammatory M2 macrophage signatures, with activation of the WNT/TGF-β signaling pathway activation and poor survival), and a non-immune class (36). The gene discussed is TGFB1; the disease is neoplasm.