HAVCR2 and head and neck squamous cell carcinoma: TIM-3 may be related to the exhaustion of CTLs and ineffective immune response in HNSCC, favoring metastatic behavior (117) In a HNSCC mouse model, anti-TIM-3 antibody induced activation of CTLs and suppressed MDSCs, inhibiting carcinogenesis and improving antitumor responses (116).