NOS3 mRNA expression in 6 of 28 tumor types, rectum adenocarcinoma (READ), STAD, PAAD, ovarian serous cystadenocarcinoma (OV), skin cutaneous melanoma (SKCM), head and neck squamous cell carcinoma (HNSC), was much higher than that in corresponding normal tissues, with statistical significance. This evidence concerns the gene NOS3 and head and neck squamous cell carcinoma.