NOS3 mRNA expression in 6 of 28 tumor types, rectum adenocarcinoma (READ), STAD, PAAD, ovarian serous cystadenocarcinoma (OV), skin cutaneous melanoma (SKCM), head and neck squamous cell carcinoma (HNSC), was much higher than that in corresponding normal tissues, with statistical significance. The gene discussed is NOS3; the disease is neoplasm.