Many glycolysis-related genes identified upregulated in CRC contains hypoxiainducible factor-1 α (HIF-1 α) (9–12), glucose transporter family (GLUT) (13–15), hexokinase (HK) (16), pyruvate kinase (PKM) (17, 18), pyruvate dehydrogenase kinases (PDK) (11) and lactate dehydrogenase A(LDHA) (12, 15). This evidence concerns the gene LDHA and colorectal carcinoma.